Arévalo, B., Bedoya, M., Kiper, A.K., Vergara F, Ramírez D, Mazola Y, Bustos D, Zúñiga R, Cikutovic R, Cayo A, Rinné S, Ramirez-Apan MT, Sepúlveda FV, Cerda O, López-Collazo E, Decher N, Zúñiga L, Gutierrez M, González W.Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. J Med Chem. 2022 Nov 24;65(22):15014-15027. doi: 10.1021/acs.jmedchem.1c00378.

López-Moncada, F., Torres, M.J., Lavanderos, B., Cerda, O., Castellón, E.A., Contreras, H.R. SPARC Induces E-Cadherin Repression and Enhances Cell Migration through Integrin αvβ3 and the Transcription Factor ZEB1 in Prostate Cancer Cells. Int J Mol Sci. (2022) May 24;23(11):5874. doi: 10.3390/ijms23115874.

Maldonado, F., Morales, D., Díaz-Papapietro, C., Valdés, C., Fernandez, C., Valls, N., Lazo, M., Espinoza, C., González, R., Gutiérrez, R., Jara, Á., Romero, C., Cerda, O., Cáceres, M. Relationship Between Endothelial and Angiogenesis Biomarkers Envisage Mortality in a
Prospective Cohort of COVID-19 Patients Requiring Respiratory Support. Front Med (Lausanne). (2022) Mar 16;9:826218. doi: 10.3389/fmed.2022.826218. eCollection 2022.

González-Avendaño, M., Zúñiga-Almonacid, S., Silva, I., Lavanderos, B., Robinson, F., Rosales-Rojas, R., Durán-Verdugo, F., González, W., Cáceres, M., Cerda, O., Vergara-Jaque, A. PPI-MASS: An Interactive Web Server to Identify Protein-Protein Interactions From Mass Spectrometry-Based Proteomics Data. Front Mol Biosci. (2021) Jul 1;8:701477. doi: 10.3389/fmolb.2021.701477.

Saldías, MP., Maureira, D., Orellana-Serradell, O., Silva, I., Lavanderos, B., Cruz, P., Torres, C., Cáceres, M., Cerda, O. TRP Channels Interactome as a Novel Therapeutic Target in Breast Cancer. Front Oncol. (2021) doi: 10.3389/fonc.2021.621614.

Riquelme, D., Cerda, O., Leiva-Salcedo, E. TRPM4 Expression During Postnatal Developmental of Mouse CA1 Pyramidal Neurons. Front Neuroanat. (2021) doi: 10.3389/fnana.2021.643287.

Fernandez, C., Burgos, A., Morales, D., Rosales-Rojas, R., Canelo, J., Vergara-Jaque, A., Vieira, GV., da Silva, RAA., Sales, KU., Conboy, MJ., Bae, EJ., Park, KS., Torres, VA., Garrido, M., Cerda, O., Conboy, IM., Cáceres, M. TMPRSS11a is a novel age-altered, tissue specific regulator of migration and wound healing. FASEB J. (2021) May;35(5):e21597. doi: 10.1096/fj.202002253RRR.

Garrido, M., Morales, D., Saldías, MP., Fernández, C., Villalobos, V., Cerda, O., Cáceres, M. Cellular response of human apical papilla cells to calcium hydroxide and tricalcium silicate-based cements. BMC Oral Health. (2021) doi: 10.1186/s12903-021-01467-6.

Jimenez, I., Prado, Y., Marchant, F., Otero, C., Eltit, F., Cabello-Verrugio, C., Cerda, O., Simon, F. TRPM Channels in Human Diseases. Cells. (2020) doi: 10.3390/cells9122604.

Lavanderos, B., Silva, I., Cruz, P., Orellana-Serradell, O., Saldías, M.P., Cerda, O. TRP Channels Regulation of Rho GTPases in Brain Context and Diseases. Front. Cell. Dev. Biol. (2020) https://doi.org/10.3389/fcell.2020.582975

Canales, J., Cruz, P., Díaz, N., Riquelme, D., Leiva-Salcedo, E., Cerda, O. K+ Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca2+ Signaling and Rac1 Activity. Cells (2020). doi: 10.3390/cells9102273.

Cardenas, C., Lovy, A., Silva-Pavez, E., Urra, F., Mizzoni, C., Ahumada-Castro, U., Bustos, G., Jaňa, F., Cruz, P., Farias, P., Mendoza, E., Huerta, H., Murgas, P., Hunter, M., Rios, M., Cerda, O., Georgakoudi, I., Zakarian, A., Molgó, J., Foskett, JK. Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival. Sci Signal. (2020). doi: 10.1126/scisignal.aay1212.

Maldonado, F., Morales, D., Gutiérrez, R., Barahona, M., Cerda, O., Cáceres, M. Effect of sevoflurane and propofol on tourniquet-induced endothelial damage: a pilot randomized controlled trial for knee-ligament surgery. BMC Anesthesiol. (2020). doi: 10.1186/s12871-020-01030-w.

Rivas, J., Díaz, N., Silva, I., Morales, D., Saldías, M.P., Pulgar, E., Cruz, P., Álvarez, A., Colombo, A., Blanco, C., Lavanderos, B., Contreras, H.R., Jaña, F., Gallegos, I., Varela, D., Trimmer, J.S., Cáceres, M., Cerda, O. KCTD5, a novel TRPM4-regulatory protein required for focal adhesion turnover and cell migration as a new predictor for breast cancer prognosis. FASEB J. (2020). doi: 10.1096/fj.201901195RRR

Jaña, F., Bustos, G., Rivas, J., Cruz, P., Urra, F., Basualto-Alarcón, C., Sagredo, E., Ríos, M., Lovy, A., Dong, Z., Cerda, O., Madesh, M., Cárdenas, C. Complex I and II are required for normal mitochondrial Ca2+ homeostasis. Mitochondrion. (2019) 49:73-82. doi: 10.1016/j.mito.2019.07.004

Canales, J. Morales, D., Blanco, C., Rivas, J. Díaz, N., Angelopoulos, I., Cerda, O. A TR(i)P to cell migration: new roles of TRP channels in mechanotransduction and cancer disease. Front Physiol (2019). doi: 10.3389/fphys.2019.00757

Blanco, C., Morales, D., Mogollones, I., Vergara-Jaque, A., Vargas, C., Álvarez, A., Riquelme, D., Leiva-Salcedo, E., González, W., Morales, D., Maureira, D., Aldunate, I., Cáceres, M., Varela, D., Cerda, O. EB1- and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion. FASEB J. (2019). doi: 10.1096/fj.201900136R.

Campos-Mora, M., Contreras-Kallens, P., Gálvez-Jirón, F., Rojas, M., Rojas, C., Refisch, A., Cerda, O., Pino-Lagos, K. CD4+Foxp3+T Regulatory Cells Promote Transplantation Tolerance by Modulating Effector CD4+ T Cells in a Neuropilin-1-Dependent Manner. Front Immunol. (2019) doi: 10.3389/fimmu.2019.00882

Riquelme, D., Silva, I., Philp, A.M., Huidobro-Toro, J.P., Cerda, O., Trimmer, J.S., Leiva-Salcedo, E. Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3. Front Cell Neurosci. (2018) doi: 10.3389/fncel.2018.00012.

Álvarez, A., Uribe, F., Canales, J., Romero, C., Soza, A., Peña, M.A., Antonelli, M., Almarza, O., Cerda, O., Toledo, H. KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence. Front Cell Infect Microbiol. (2017). doi: 10.3389/fcimb.2017.00450.

Mendoza P.A., Silva, P., Díaz, J., Arriagada, C., Canales, J., Cerda, O., Torres, V.A. Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration. Cell Adh Migr. (2017) doi: 10.1080/19336918.2017.1377388

Saldías, M.P., Fernández, C., Morgan, A., Díaz, C., Morales, D., Jaña, F., Gómez, A., Silva, A., Briceño, F., Oyarzún, A., Maldonado, F., Cerda, O., Smith, P.C., Cáceres, M. Aged blood factors decrease cellular responses associated with delayed gingival wound repair. PLoS One. (2017), e0184189.

Leiva-Salcedo, E., Riquelme, D., Cerda, O., Stutzin, A. TRPM4 activation by chemically- and oxygen deprivation-induced ischemia and reperfusion triggers neuronal death. Channels (2017) doi: 10.1080/19336950.2017.1375072.

Sagredo, A., Sagredo, E., Cappelli, C., Baez, P., Andaur, R., Blanco, C., Tapia, J., Echeverria, C., Cerda, O., Stutzin, A., Simon, F., Marcelain, K., Armisen, R. TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells. Mol. Oncol. (2017) doi: 10.1002/1878-0261.12100.

Signore, I.A., Jerez, C., Figueroa, D., Suazo, J., Marcelain, K., Cerda, O., Colombo, A. Inhibition of the 3-hydroxy-3-methyl-glutaryl-CoA reductase induces orofacial defects in zebrafish. Birth Defects Research Part A: Clinical and Molecular Teratology (2016), doi: 10.1002/bdra.23546.

Caceres, M., Ortiz, L., Recabarren, T., Romero, A., Colombo, A., Leiva-Salcedo, E., Varela, D., Rivas, J., Silva, I., Morales, D., Campusano, C., Almarza, O., Simon, F., Toledo, H., Park, K.S., Trimmer, J.S., Cerda, O. TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility. PLoS One 10 (2015), e0130540.

Cerda, O., Cáceres, M., Park, K.S., Leiva-Salcedo, E., Romero, A., Varela, D., Trimmer, J.S., Stutzin, A. Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca2+-activated non-selective cation channel TRPM4. Pflügers Archiv- Eur. J. Physiol. 467 (2015): 1723-1732.

Sarmiento, D., Montorfano, I., Cerda, O., Cáceres, M., Becerra, A., Cabello-Verrugio, C., Elorza, A.A., Riedel, C., Tapia, P., Velásquez, L.A., Varela, D., Simon, F. Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel. Microvasc Res. (2015) 98:187-196.

Sarmiento, D., Montorfano, I., Cáceres, M., Echeverría, C., Fernández, R., Cabello-Verrugio, C., Cerda, O., Tapia, P., Simon, F. Endotoxin-induced vascular endothelial cell migration is dependent on TLR4/NF-κB pathway, NAD(P)H oxidase activation, and transient receptor potential melastatin 7 calcium channel activity. Int. J. Biochem. Cell. Biol. 55 (2014): 11-23.

Mandikian, D., Bocksteins, E., Parajuli, L., Bishop, H., Cerda, O., Shigemoto, R., Trimmer, J.S. Cell type specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors. J. Comp. Neurol. 522 (2014): 3555-3574.

Valenzuela, M., Cáceres, A., Almarza, O., Bravo, D., Soto, S., Cerda, O., Toledo, H. Characterization of the arginine decarboxylase gene (ORF HP0422) involved in acid tolerance in Helicobacter pylori. Helicobacter 19 (2014): 182-193.

Cerda O., Nuñez-Villena F., Soto S.E., Ugalde J.M., López-Solís R., Toledo H. tlpA gene expression is required for arginine and bicarbonate chemotaxis in Helicobacter pylori. Biol Res 44 (2011): 277-282.

Cerda, O., Trimmer, J. S. Activity-Dependent Phosphorylation of Neuronal Kv2.1 Potassium Channels by CDK5. J. Biol. Chem. 286 (2011): 28738–28748. (Highlighted on the Cover)

Mandikian, D., Cerda, O., Sack, J. T., Trimmer, J. S. A SUMO-Phospho tag team for wrestling with potassium channel gating. J. Gen. Physiol. 137 (2011): 435-439.

Baek, J. H., Cerda, O.*, Trimmer, J. S. Mass spectrometry-based phosphoproteomics reveals multisite phosphorylation on mammalian brain voltage-gated sodium and potassium channels. Semin. Cell Dev Biol 22 (2011): 153-159 * Equal contribution. (Highlighted on the Cover)

Vacher, H., Yang, J. Y., Cerda, O., Autillo-Touati, A., Dargent, B., Trimmer, J. S. CDK-mediated phosphorylation of the Kvβ2 auxiliary subunit regulates Kv1 channel axonal targeting. J. Cell Biol. 192 (2011): 813-824. (Highlighted in Faculty of 1000)

Cerda, O., Baek, J. H., Trimmer, J. S. Mining recent brain proteomic databases for ion channel phosphosite nuggets. J. Gen. Physiol. 137 (2011): 3–16.

Simon, F., Leiva-Salcedo, E., Armisén, R., Riveros, A., Cerda, O., Eguiguren, A., Olivero, P., Stutzin, A. Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death. J. Biol. Chem. 285 (2010): 37150-37158.

Cerda, O., Trimmer, J. S. Analysis and functional implications of phosphorylation of neuronal voltage-gated potassium channels. Neuroscience Letters 10 (2010): 486(2): 60-67.

Varela, D., Penna, A., Simon, F., Eguiguren, A. L., Leiva-Salcedo, E., Cerda, O., Sala, F., Stutzin, A. P2X4 activation modulates volume-sensitive outwardly rectifying chloride channels in rat hepatoma cells. J. Biol Chem. 285 (2010): 7566-7574.

Valenzuela, M., Cerda, O., Toledo, H. An overview on chemotaxis an Acid resistance in Helicobacter pylori. Biol. Research, 36 (2003): 429-436.

Vallejos, C., Cerda, O., Valenzuela, M., Toledo, H. Resistencia antimicrobiana en Helicobacter pylori: Aspectos clínicos y moleculares Rev. Med. Chil., 131 (2003): 1313-1320.

Cerda, O., Rivas, A., Toledo, H. Helicobacter pylori strain ATCC700392 encodes a methyl-accepting chemotaxis receptor protein (MCP) for arginine and sodium bicarbonate. FEMS Letters, 224 (2003): 175-181.