We offer three thesis topics (3 years) for Ph.D. students in the area of biological sciences. These topics focus on:
1) Characterization of the proteome of Orai-STIM channels dependent on ubiquitination.
2) Characterization of the ubiquitination-dependent proteome of SOCE response regulatory proteins.
3) Participation of the KCTD5 protein in senescence of breast cancer cells.
4) Identification of ion channels required for focal adhesion and cell migration dynamics.
These studies consider the use of advanced biochemical techniques (immunoprecipitation, mass spectrometry), molecular biology (recombinant DNA, site-directed mutagenesis, lentivirus generation), and cell biology (primary culture, migration assays, Ca2+ imaging, BRET, and FRET). In addition, these studies consider the generation of genetically encoded sensors for sodium, potassium, chloride, and calcium.
– Proactivity and enthusiasm.
– Scientific interest.
These are part of the Fondecyt Regular Grant 1200917 and the Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD).